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Scientific Reports

Withaferin A (WIT) interaction with β–Tubulin

دکتر مهدی نباتی مدرس شیمی کنکور و دبیرستان متخصص شیمی آلی سنتز و فرمولاسیون دارو و طراحی دارو

Withaferin A (WIT) interaction with β–Tubulin Withaferin A (WIT) Withaferin A (WIT) is an important natural compound extracted from the Indian medicinal plant Withania somnifera. This plant has been used for over 3000 years in Unani Indian medical system. Also, its extracted medicinal compound has been in ayurvedic medicine and …

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Design of novel tazarotene derivatives

دکتر مهدی نباتی مدرس شیمی کنکور و دبیرستان متخصص شیمی آلی سنتز و فرمولاسیون دارو و طراحی دارو

Design of novel tazarotene derivatives as potential antipsoriatic drugs   What is Psoriasis? Psoriasis is a prevalent chronic inflammatory skin condition afflicting about 2-4% of patients all over the world. Psoriasis is mostly characterized by the skin covered with red, well-defined, hardened plaques with silver and micaceous scale. Complications associated …

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Molecular structure and stability of 99mTc-MDP

دکتر مهدی نباتی مدرس شیمی کنکور و دبیرستان متخصص شیمی آلی سنتز و فرمولاسیون دارو و طراحی دارو

The molecular structure and the stability parameters of 99mTc-MDP Medronate, commonly known as methylene diphosphonate or MDP, is the smallest bisphosphonates, recognized as a family of drugs used in treatment of various bone diseases. Bisphosphonates are the structural analogs of native pyrophosphate with a P-C-P backbone instead of P-O-P. The …

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Irilone as a progesterone receptor (PR) effect supporter in endometrial and ovarian cancer cell lines

Dr. Mehdi Nabati Iranian Drug Designer

Irilone as a progesterone receptor (PR) effect supporter in endometrial and ovarian cancer cell lines   Estrogen and Progesterone receptors (ER, PR) are ligand-induced transcription factor members of the steroid hormone receptor (SR) subfamily of nuclear receptors. Those receptors and their corresponding steroid hormones (estradiol and progesterone) play their roles …

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zotepine as an atypical antipsychotic antagonist

Physicochemical properties analysis and dopamine D2 receptor (D2R) docking of zotepine as an atypical antipsychotic antagonist

Zotepine as an atypical antipsychotic antagonist Schizophrenia is a chronic, critical condition characterized by collective psychotic signs and symptoms, exhibited as alterations in patient’s thoughts, perception and behavioral attributes. Schizophrenia is mostly accompanied by symptoms that are generally categorized into two major groups: 1: Positive symptoms including hallucinations (auditory, visual, …

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Arketamine for Major Depressive Disorder (MDD) treatment

Major Depressive Disorder (MDD) treatment

Arketamine for Major Depressive Disorder (MDD) treatment Major depressive disorder (MDD) is one of the most infamous and oldest medical conditions determined by disturbances of cognition as well as neurovegetative and psychomotor functions. The World Health Organization estimates the number of individuals afflicted by MDD to be well over 300 …

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Esketamine for Major Depressive Disorder (MDD) treatment

esketamine for Major Depressive Disorder (MDD) treatment

Esketamine for Major Depressive Disorder (MDD) treatment Major depressive disorder or MDD is a serious neurological condition that afflicts almost 300 million people around the world. Over the years, various classes of antidepressants have been developed. Although the efforts to manage MDD have been fruitful in many cases, still about …

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Novel drugs for autism treatment

novel drugs based on zonisamide

Novel drugs for autism treatment Autism spectrum disorders (ASDs) are complex and prevalent neurodevelopmental disorders predominantly diagnosed through observation of a wide variety of atypical behavior, expressed by impairments in socialization, communication, thinking, interests, activities and cognitive skills as well as restricted and repetitive behavior. Autism is considered a heterogeneous …

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Metoclopramide as a small molecule of dopamine D2 receptor

In Silico Study of Metoclopramide as A Small Molecule of Dopamine D2 Receptor

 Metoclopramide as a small molecule of dopamine D2 receptor Dopamine D2 receptor (D2R) has been constructed from various natural amino acids in humans that is encoded by DRD2 gene. This protein (D2R) is the most important receptor for many antipsychotic medicines. The D2R structure has been known using a radiolabeled …

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