خانه / Scientific Reports

Scientific Reports

Arketamine for Major Depressive Disorder (MDD) treatment

Major Depressive Disorder (MDD) treatment

Arketamine for Major Depressive Disorder (MDD) treatment Major depressive disorder (MDD) is one of the most infamous and oldest medical conditions determined by disturbances of cognition as well as neurovegetative and psychomotor functions. The World Health Organization estimates the number of individuals afflicted by MDD to be well over 300 …

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Esketamine for Major Depressive Disorder (MDD) treatment

esketamine for Major Depressive Disorder (MDD) treatment

Esketamine for Major Depressive Disorder (MDD) treatment Major depressive disorder or MDD is a serious neurological condition that afflicts almost 300 million people around the world. Over the years, various classes of antidepressants have been developed. Although the efforts to manage MDD have been fruitful in many cases, still about …

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Novel drugs for autism treatment

novel drugs based on zonisamide

Novel drugs for autism treatment Autism spectrum disorders (ASDs) are complex and prevalent neurodevelopmental disorders predominantly diagnosed through observation of a wide variety of atypical behavior, expressed by impairments in socialization, communication, thinking, interests, activities and cognitive skills as well as restricted and repetitive behavior. Autism is considered a heterogeneous …

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Metoclopramide as a small molecule of dopamine D2 receptor

In Silico Study of Metoclopramide as A Small Molecule of Dopamine D2 Receptor

 Metoclopramide as a small molecule of dopamine D2 receptor Dopamine D2 receptor (D2R) has been constructed from various natural amino acids in humans that is encoded by DRD2 gene. This protein (D2R) is the most important receptor for many antipsychotic medicines. The D2R structure has been known using a radiolabeled …

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Introducing a novel source of carbene on pyridine ring

Diaminopyridine

Introducing a novel source of carbene on pyridine ring for the first time ۲,۶-Diaminopyridine (2,6-DAP) is formally prepared from pyridine by substitution of the 2 and 6 positions with an amino group under severe conditions. It is a medium-production-volume chemical used as a pharmaceutical intermediate and a hair dye coupler …

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۱۱C-LY2795050 as a novel antagonist tracer for PET scan of the kappa (κ) and mu (µ) opioid receptors

Dr. Mehdi Nabati Professor of Organic Chemistry

۱۱C-LY2795050 Radiopharmaceutical A receptor into the cells has two main operations when it makes complex with an agonist compound and or an antagonist molecule. The agonist-receptor complex formation causes the receptor activation, but the binding of antagonist molecule to the receptor causes its blocking. In pharmacology, the antagonist compounds have …

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