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خانه / مقالات خبری / Dr. Mehdi Nabati

Dr. Mehdi Nabati

Dr. Mehdi Nabati

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Mehdi Nabati

Ph.D. of Organic Chemistry

Date of Birth: 22/04/1988

Place of Birth: Maragheh, East Azarbaijan, Iran

Marital Status: Single

Mobile Number: +989011828140

E-mail: mnabati@ymail.com

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Doctor Mehdi Nabati
Dr. Mehdi Nabati

EDUCATION AND RESEARCH

Azarbaijan Shahid Madani University, Tabriz, Iran

. Ph.D., Organic Chemistry, with Dr. Mehrdad Mahkam, Sept. 2012 – ۲۰۱۵

Project: Synthesis and computational study of structural properties and stability of novel polynitrogen compounds

. M.S., Phytohemistry, with Dr. Mehrdad Mahkam, Sept. 2010 – ۲۰۱۲

Project: Extraction of curcumin from turmeric powder and preparation some of its derivatives

Mazandaran University, Babolsar, Iran

. B.S., Applied Chemistry, Sept. 2006 – ۲۰۱۰

Seminar: Chemistry of high energy materials

REFERENCES

Dr. Mehrdad Mahkam

Professor of organic Chemistry

Faculty of Sciences,

Azarbaijan Shahid Madani University,

P.O.Box: 53714-161,

Tabriz-Iran.

E-mail: mmahkam@yahoo.com, mmahkam@gmail.com

PUBLICATIONS

  1. Nabati, M.; Mahkam, M. pH-sensitive nano carriers for oral-curcumin delivery. Iranian Journal of Organic Chemistry. 2013, 5, 1157-1161.
  2. Nabati, M.; Mahkam, M. Synthesis and characterization of novel silyl derivatives of curcumin. Iranian Chemical Communication. 2014, 2, 129-136.
  3. Nabati, M.; Mahkam, M.; Heidari, H. Isolation and characterization of curcumin from powdered rhizomes of turmeric plant marketed in Maragheh city of Iran with soxhlet technique. Iranian Chemical Communication. 2014, 2, 236-243.
  4. Nabati, M.; Mahkam, M. Computational study of octasilacubane structural properties with density functional theory method. Silicon. 2015, 7, Published Online.
  5. Mahkam, M.; Nabati, M.; Latifpour, A.; Aboudi, J. Synthesis and characterization of new nitrogen-rich polymers as candidates for energetic applications. Designed Monomers and Polymers. 2014, 17, 453-457.
  6. Nabati, M.; Mahkam, M. Density functional theory study of the structural and energetically properties of 1H-tetrazolyl cubane as high energy density material. Iranian Journal of Organic Chemistry. 2014, 6, 1331-1339.
  7. Mahkam, M.; Nabati, M.; Kafshboran, H. R. Isolation, identification and characterization of lawsone from henna leaves powder with soxhlet technique. Iranian Chemical Communication. 2014, 2, 34-38.
  8. Nabati, M.; Mahkam, M. One-pot and one-step novel N-methylation of 2, 6-Diaminopyridine. Iranian Chemical Communication. 2014, 2, 164-169.
  9. Nabati, M.; Mahkam, M. Effect of nitro and amino substituents on structural and energetically properties of 1,2,4,5- tetrazine: DFT and ab-initio study. Iranian Journal of Organic Chemistry. 2014, 6, 1397-1405.
  10. Mahkam, M.; Namazifar, Z.; Nabati, M.; Aboudi, J. Synthesis and characterization of new 5-substituted 1H-tetrazoles in water: a greener approach. Iranian Journal of Organic Chemistry. 2014, 6, 1217-1220.
  11. Mahkam, M.; Kafshboran, H. R.; Nabati, M. Synthesis and characterization of novel colored polymers based on lawsone natural compound. Designed Monomers and Polymers. 2014, 17, 784-794.
  12. Nabati, M.; Mahkam, M. DFT Study of 1H-tetrazolyl derivatives of tetrahedrane. Journal of Physical and Theoretical Chemistry. 2015, 12, 33-43.
  13. Teymori, A.; Amiri, S.; Massoumi, B.; Mahkam, M.; Nabati, M. Modern ionic liquid functionalized silica nanoparticles as carriers for oral drug delivery. Iranian Journal of Organic Chemistry. 2014, 6, 1287-1291.
  14. Nabati, M.; Mahkam, M. Molecular modeling of most stable configurations of azocubane: DFT study of structural and energetically properties. Iranian Journal of Organic Chemistry. 2015, 7, 1463-1472.
  15. Nabati, M.; Mahkam, M. Synthesis and characterization of PTS and PDATS: Two maiden functionalized energetic polymers having tetrazole and triazine rings. Iranian Journal of Organic Chemistry. 2015, 7, 1419-1425.
  16. Nabati, M.; Mahkam, M. A quantum-mechanical study on nitro and amino derivatives of 1,2,3,4-tetrazine. Journal of Physical and Theoretical Chemistry. 2015, 12, 121-136.
  17. Nabati, M.; Mahkam, M. A theoretical study of the structural and energetically properties on the 1,4-bis(1H-tetrazolyl)cubane: an ab-initio treatment. Iranian Journal of Organic Chemistry. 2015, 7, 1503-1513.
  18. Nabati, M.; Mahkam, M. Synthesis, characterization and computational study of novel highly heatresistant nitrogen-rich polymers based on 1H-tetrazole rings. Iranian Journal of Organic Chemistry. 2015, 7, 1537-1546.
  19. Aboudi, J.; Bayat, Y.; Abedi, Y.; Nabati, M.; Mahkam, M. 3-Nitro, 1-Amino Guanidine and 5-Hydrazino-1H Tetrazole Derivatives as New Energetic Materials. Iranian Journal of Chemistry and Chemical Engineering. 2015, 34, 1-16.
  20. Nabati, M. Important factors determination on turmeric properties through curcumin reaction with boric acid and oxalic acid. Iranian Journal of Organic Chemistry. 2015, 7, 1577-1580.
  21. Nabati, M. DFT study of the six-membered heterocyclic SinN6-nHn (n = 0-6): stability and aromaticity. Organic Chemistry Research. 2016, 2, 70-80.
  22. Nabati, M. A quantum-mechanical investigation of functional group effect on 5,5′-disubstituted-1,1′-azobis(tetrazoles). Journal of Physical and Theoretical Chemistry. 2015, 12, 325-338.
  23. Nabati, M. Density functional theory study of molecular structure, chemical reactivity and radical scavenging potency of (+)-curcutetraol. Iranian Journal of Organic Chemistry. 2015, 7, 1631-1640.
  24. Nabati, M. 1,3,4-Thiadiazole rings as π-spacers in triphenylamine based dyes: A density functional theory study of reactivity, UV/Visible spectra, structural and optical properties. Iranian Journal of Organic Chemistry. 2015, 7, 1669-1678.
  25. Nabati, M. A DFT treatment on nitro derivatives of pyrazine. Iranian Journal of Organic Chemistry. 2016, 8, 1703-1716.
  26. Nabati, M.; Mahkam, M.; Atani, Y. G. Theoretical study of tetrahedrane derivatives. Journal of Physical and Theoretical Chemistry. 2016, 13, 35-59.
  27. Nabati, M. A computational study on the 5-substituted 1H-tetrazoles: Structure, stability and aromaticity. Iranian Journal of Organic Chemistry. 2016, 8, 1803-1810.
  28. Nabati, M.; Hojjati, M. Structural and energetically study on nitro and amino derivatives of 1,2,3,5-tetrazine. Iranian Journal of Organic Chemistry. 2016, 8, 1777-1787.
  29. Nabati, M. Density functional theory study of the structural properties of cis-trans isomers of bis-(5-nitro-2H-tetrazolato-N2) tetraammine cobalt (III) perchlorate (BNCP). Journal of Physical and Theoretical Chemistry. 2016, 13, 133-146.
  30. Nabati, M. DFT investigation of 1,1′-disubstituted-5,5′-azotetrazoles: a study of functional group effect. Iranian Journal of Organic Chemistry. 2016, 8, 1817-1825.
  31. Nabati, M.; Mahkam, M. Natural bond orbital (NBO) study of (5H-tetrazol-1-yl)(triphenylphosphine)gold [Au(tetz)(PPh3)]. Inorganic Chemistry Research. 2016, 1, 131-140.
  32. Nabati, M. Quantum-chemical study of stability, aromaticity and reactivity properties on O- and S-heterocyclic divalent five-membered rings C2H2X2M (X=O and S; M=C, Si, Ge, Sn and Pb). Iranian Journal of Organic Chemistry. 2016, 8, 1935-1944.
  33. Nabati, M.; Mofrad, M. H.; Kermanian, M.; Sarshar, S. Theoretical studies on the structural properties, aromaticity and reactivity of 1H-phosphole derivatives. Iranian Journal of Organic Chemistry. 2017, 9, 1981-1993.
  34. Nabati, M.; Salehi, H. Theoretical investigation on the 1H and 13C chemical shifts of TRODAT-1 compound with density functional theory and Hartree-Fock computational methods. Iranian Journal of Organic Chemistry. 2017, 9, 2013-2023.
  35. Nabati, M.; Kermanian, M.; Maghsoudloo-Mahalli, A.; Sarshar, S. DFT study of [18F]flubatine. Iranian Journal of Organic Chemistry. 2017, 9, 2067-2077.
  36. Nabati, M. Quantum-mechanical investigation of 1-benzyl-1,4,7,10-tetraazacyclododecane a density functional theory (DFT) treatment. Iranian Journal of Organic Chemistry. 2017, 9, 2045-2055.
  37. Nabati, M.; Mohammadnejad-Mehrabani, H. A novel method for purification of the synthesized Br-HIDA compound and its identification by FT-IR and HPLC techniques in Pars Isotope Company. Iranian Journal of Organic Chemistry. 2017, 9, 2117-2121.
  38. Nabati, M.; Maghsoudloo-Mahalli, A. A theoretical study of structural and spectral properties on [18F]FDG radiopharmaceutical. Iranian Journal of Organic Chemistry. 2017, 9, 2239-2247.
  39. Nabati, M. Prediction of the structural and spectral properties and reactivity of the silicon analogs of cyclobutadiene C4-nSinH4 (n= 0-4) by density functional theory computations. Chemical Methodologies. 2017, 1, 121-135.
  40. Nabati, M. Prediction of the structural and spectral properties for L,L-ethylenedicysteine diethylester (EC) and its complex with Technetium-99m radionuclide. Journal of Physical and Theoretical Chemistry. 2017, 14, 49-61.
  41. Nabati, M.; Kermanian, M.; Mohammadnejad-Mehrabani, H.; Kafshboran, H. R.; Mehmannavaz, M.; Sarshar, S. Theoretical investigation on the antitumor drug: ThioTEPA and its interaction with S-donor biomolecules and DNA purine bases. Chemical Methodologies. 2018, 2, 128-140.
  42. Nabati, M. Insight into the Stability, Reactivity, Structural and Spectral Properties of the Anti, Syn-endo and Syn-exo Isomers of Bis(N-ethoxy-N-ethyl-dithiocarbamato)Nitrido Technetium-99m [99mTc-N(NOEt)2] Radiopharmaceutical. Chemical Methodologies. 2018, 2, 223-238.
  43. Nabati, M. Structural and spectral (IR, UV-Vis, CD and DOS) properties of active substance d,l-HMPAO and its complex with technetium-99m radionuclide 99mTc-exametazime. Iranian Journal of Organic Chemistry. 2018, 10, 2457-2465.
  44. Nabati, M. Prediction of spectral (IR and UV-Vis) and Structural properties of active substance 3-(carboxymethyl)-3-hydroxypentanedioic acid (CMHPDA) and its complex with gallium-67 radioisotope 67Ga-3-(carboxylatomethyl)-3-hydroxypentanedionate (67Ga-CMHPDA). Iranian Journal of Organic Chemistry. 2018, 10, 2409-2416.
  45. Nabati, M. Reactivity and aromaticity of hexasiline derivatives Si6XH5 (X = H, F, Cl, Br, COOH, NO2, NH2, CH3 and tBu). Journal of Physical and Theoretical Chemistry. 2017, 14, 283-293.
  46. Nabati, M. Insight into the structural and spectral (IR and UV-Vis) properties of the salts of alkali (Li, Na and K) and alkaline earth (Be, Mg and Ca) metals with pertechnetate oxoanion (99mTcO4) as the convenient water-soluble sources of the radioactive element technetium. Asian Journal of Green Chemistry. 2019, 3, 258-270.
  47. Nabati, M.; Sabahnoo, H.; Lohrasbi, E.; Mazidi, M. Structural properties study and spectroscopic (FT-IR and UV-Vis) profiling of the novel antagonist LY2157299 as a transforming growth factor-β (TGF-β) receptor I kinase inhibitor by quantum-mechanical (QM) and molecular docking techniques. Chemical Methodologies. 2019, 3, 383-397.
  48. Nabati, M.; Maghsoudloo-Mahalli, A.; Mohammadnejad-Mehrabani, H.; Movahed-Tazehkand, H. A novel two-step method for synthesis, purification and characterization of mebrofenin in Pars Isotope Company. Iranian Journal of Organic Chemistry. 2018, 10, 2281-2285.
  49. Nabati, M. Structural and spectral study of MAG3 molecule. Iranian Journal of Organic Chemistry. 2018, 10, 2291-2299.
  50. Nabati, M.; Sabahnoo, H. Spectroscopic (FT-IR and UV-Vis), electronic and docking studies on the red clover isoflavone irilone as a progesterone receptor (PR) effect supporter in endometrial and ovarian cancer cell lines. Journal of Medicinal and Chemical Sciences. 2019, 2, 118-125.
  51. Nabati, M. Modeling and interactions analysis of the novel antagonist agent flibanserin with 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor as a HSDD treatment in premenopausal women. Iranian Chemical Communication. 2019, 7, 324-334.
  52. Nabati, M.; Lohrasbi, E.; Sabahnoo, H.; Bodaghi-Namileh, V.; Mazidi, M.; Mohammadnejad-Mehrabani, H.; Tavakkoli, A.; Gravand, A. In silico study of Metoclopramide as a small molecule of dopamine D2 receptor: a quantum-mechanical (QM) based molecular docking treatment. Chemical Methodologies. 2020, 4, 19-33.
  53. Nabati, M.; Bodaghi-Namileh, V. Molecular modeling of 3-(1,3-dioxoisoindolin-2-yl) benzyl nitrate and its molecular docking study with phosphodiesterase-5 (PDE5). Advanced Journal of Chemistry-Section A. 2020, 3, 58-69.
  54. Nabati, M. Exploring molecular docking and electronic studies of [11C]LY2795050 as a novel antagonist tracer for positron emission tomography (PET) scan of the kappa (κ) and mu (µ) opioid receptors (KOR and MOR). Journal of Medicinal and Chemical Sciences. 2020, 3, 22-34.
  55. Nabati, M.; Bodaghi-Namileh, V.; Sarshar, S. Molecular Modeling of the antagonist compound esketamine and its molecular docking study with non-competitive N-methyl-D-aspartate (NMDA) receptors NR1, NR2A, NR2B and NR2D. Progress in Chemical and Biochemical Research. 2019, 2, 108-119.
  56. Nabati, M.; Bodaghi-Namileh, V. Design of novel drugs (P3TZ, H2P3TZ, M2P3TZ, H4P3TZ and M4P3TZ) based on Zonisamide for autism treatment by binding to potassium voltage-gated channel subfamily D member 2 (Kv4.2). International Journal of New Chemistry. 2019, 6, 254-276.
  57. Nabati, M.; Bodaghi-Namileh, V. In silico study of the active components (17α-ethinyl estradiol and segesterone acetate) of annovera as a novel vaginal contraceptive system by docking of their binding to estrogen and progesterone receptors. Eurasian Chemical Communication. 2020, 2, 234-246.
  58. Nabati, M.; Bodaghi-Namileh, V. Non-competitive N-methyl-D-aspartate (NMDA) receptor (NR2B) structure in complex with antidepressant arketamine. Iranian Journal of Organic Chemistry. 2019, 11, 2591-2598.
  59. Davarpanah, M.; Abbasi, H.; Nabati, M.; Sabahnoo, H.; Bodaghi-Namileh, V.; Mazidi, M.; Movahhed-Tazehkand, H.; Mohammadnejad-Mehrabani, H. Kit formulation of active pharmaceutical ingredient d,l-HMPAO as a brain perfusion diagnostic system. Progress in Chemical and Biochemical Research. 2019, 2, 185-191.
  60. Nabati, M.; Bodaghi-Namileh, V. Physicochemical properties analysis and dopamine D2 receptor (D2R) docking of zotepine as an atypical antipsychotic antagonist. Journal of Physical and Theoretical Chemistry. 2018, 15, 149-158.
  61. Nabati, M.; Bodaghi-Namileh, V. Evaluation of [18F]FPTT Molecular structure and its binding to progesterone receptor (PR) for PET scan of breast cancer. Journal of Physical and Theoretical Chemistry. 2018, 15, 159-171.
  62. Nabati, M.; Bodaghi-Namileh, V. Design of novel tazarotene derivatives as potential antipsoriatic drugs: physicochemical properties study and molecular docking analysis of their binding to retinoic acid receptor family (RAR-alpha, RAR-beta and RAR-gamma). Journal of Medicinal and Chemical Sciences. 2020, 3, 162-175.
  63. Nabati, M.; Sabahnoo, H.; Bodaghi-Namileh, V. Molecular Structure Determination and Stability Parameters Study of 99mTc-MDP (Technetium 99m Methylene Diphosphonate) Cold Kit and Analysis of Its Binding to Osteocalcin Receptor as a Bone Scan Agent. Chemical Methodologies. 2020, 4, 297-310.
  64. Nabati, M.; Pournamdari, E.; Dashti-Rahmatabadi, Y.; Sarshar, S. Withaferin A (WIT) Interaction with beta–Tubulin to Promote Tubulin Degradation: In Silico Study. Advanced Journal of Chemistry-Section B. 2020, 2, 26-32.

CONFRENCES

  1. Nabati, M.; Mahkam, M. Synthesis and characterization of novel nitrogen-rich compounds. 22th Iranian Organic Chemistry Conference, Tabriz, 2014.
  2. Nabati, M. Third international conference on peptide and protein sciences, Shiraz, 24-26 April 2018.
  3. Nabati, M. The third national festival and international congress on stem cell and regenerative medicine, Tehran, 28 Nov. – ۱ Dec. 2018.

RESEARCH PROJECTS

  1. Nabati, M.; Mahkam, M. Preparation of heat-resistant nitrogen-rich polymers with anti-bacterial properties. 2nd Provincial new and advanced technologies exhibition, Tabriz, 2014.
  2. Mahkam, M.; Kafshboran, H. R.; Nabati, M. Preparation of new self-color polymers based on henna plant. 2nd Provincial new and advanced technologies exhibition, Tabriz, 2014.
  3. Nabati, M.; Salehi, H.; Mohammadnejad-Mehrabani, H. Synthesis and purification of BrHIDA compound by novel method. Pars Isotope Company, Tehran, 2017.
  4. Nabati, M.; Salehi, H.; Mohammadnejad-Mehrabani, H.; Sabahnoo, H.; Lohrasbi, E.; Movahhed, H.; Karamivand, M. Synthesis and purification of d,l-HMPAO compound by novel method and production of its radiopharmaceutical kit with technetium-99m radionuclide. Pars Isotope Company, Tehran, 2017.
  5. Nabati, M.; Salehi, H.; Mohammadnejad-Mehrabani, H. Synthesis and purification of MIBI compound by novel method and production of its radiopharmaceutical kit with technetium-99m radionuclide. Pars Isotope Company, Tehran, 2018.
  6. Nabati, M.; Salehi, H.; Mohammadnejad-Mehrabani, H. Purification of BrHIDA compound by novel method. Pars Isotope Company, Tehran, 2018.
  1. Nabati, M. Potassium Chloride purification and its conversion from industrial grade to pharmaceutical grade. Shari Pharmaceutical Company, Tehran, 2019.
  2. Nabati, M. Ascorbic acid (Vitamin C) purification and its conversion from food grade to pharmaceutical grade. Shari Pharmaceutical Company, Tehran, 2019.
  3. Nabati, M. Synthesis and Formulation of Ferric Maltol. Shari Pharmaceutical Company, Tehran, 2019.

Workshops

  1. Nabati, M. Small-Angle X-Ray Scattering (SAXS). Third international conference on peptide and protein sciences, Shiraz, April 24, 2018.
  2. Nabati, M. Fast Protein Liquid Chromatography (FPLC). Third international conference on peptide and protein sciences, Shiraz, April 25, 2018.
  3. Nabati, M. Dynamic Light Scattering (DLS). Third international conference on peptide and protein sciences, Shiraz, April 26, 2018.
  4. Nabati, M. Design and analysis of clinical trials. Research Consultation Center, Shiraz, April 23th-24th, 2019.

Educational Courses

  1. Fundamentals of Nuclear Pharmacy. Professor: Dr. Ali Bahrami Samani, Pars Isotope Company, Tehran, 2017.
  2. Fundamentals of Nuclear Pharmacy. Professor: Dr. Reza Najafi, Pars Isotope Company, Tehran, 2018.
  3. Fundamentals of Freeze Dryer equipment. Professor: Dr. Kiani, Pars Isotope Company, Tehran, 2018.
  4. Introduction to Fundamentals of Clean Room. Professor: Dr. Mehdizadeh, Pars Isotope Company, Tehran, 2018.
  5. Fundamentals of Nuclear Pharmacy (quality control of radiopharmaceuticals). Professor: Dr. Beiki, Pars Isotope Company, Tehran, 2018.
  6. Fundamentals of GMP. Pars Isotope Company, Tehran, 2019.

SOCIETIES AND HONORARIES

. Iranian Chemical Society Member, From 2013 until Now

. Appreciation by the CEO of Pars Isotope Company for solving the problems of manufactured drugs, 2019

SKILLS AND EXPERTISES

Synthesis and purification of chemical compounds

Isolation and characterization of natural compounds

Synthesis of novel carriers for drug delivery

Complete familiarity with IR, UV-Vis, NMR, Mass, CHNSO, ICP, HPLC, GC, TLC, SAXS, DLS, FPLC and TgA analyses

Molecular modeling and study of the mechanisms of chemical reactions

Complete familiarity with Gaussian, Gauss View, Gauss Sum, Chemissian, Spartan, Turbomole, Hyperchem, ChemBioOffice, Molegro Virtual Docker (MVD), AutoDock Tools (ADT) and Microsoft Office (Word, PowerPoint and Excel) softwares

Production of radiopharmaceutical kits

TEACHING EXPERIENCES

General Chemistry 1

Organic Chemistry 1

Organic Chemistry 2

Organic Chemistry 3

Physical Organic Chemistry

Medicinal Chemistry

– Heterocyclic Chemistry

LANGUAGE SKILLS

Azerbaijani

Turkish

Persian

English

EXECUTIVE POSITIONS

Expert of Synthesis Lab. Pars Isotope Company, Tehran, Oct. 2016-Aug. 2018.

Head of Synthesis Lab. Pars Isotope Company, Tehran, Aug. 2018-22th Nov. 2019.

Head of the scientific workgroup of troubleshooting of routine production kits. Pars Isotope Company, Tehran, Mar. 2017-Nov. 2019.

Head of the scientific workgroup of the acquisition to the technology of modern antagonist compounds. Pars Isotope Company, Tehran, Feb. 2018-Apr. 2019.

Head of the scientific workgroup of the national Fingolimod radiopharmaceutical production project. Pars Isotope Company, Tehran, Feb. 2018-Apr. 2019.

Member of Board, The pharmaceutical projects planning committee. Pars Isotope Company, Tehran, Oct. 2018-Nov. 2019.

Qualified Person. Shari Pharmaceutical Company, Tehran, 24th Nov. 2019-19th Mar. 2020.

Member of Board, Research and Development (R&D) committee. Shari Pharmaceutical Company, Tehran, 24th Nov. 2019-19th Mar. 2020.

حتما ببینید

دکتر مهدی نباتی مدرس شیمی کنکور و دبیرستان متخصص شیمی آلی سنتز و فرمولاسیون دارو و طراحی دارو

Withaferin A (WIT) interaction with β–Tubulin

Withaferin A (WIT) interaction with β–Tubulin Withaferin A (WIT) Withaferin A (WIT) is an important …

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