بایگانی/آرشیو برچسب ها : Molecular Simulation

Substitution of carbonyl group of ellagic acid with silanediol group for better inhibition of VEGFR-2 Kinase enzyme What is cancer? The major cause of death worldwide is cancer. Surgery, chemotherapeutic agents and radiation which are cancer therapy have not been much efficient in the reduction of cancer occurrence and raising …

FPTT for PET scan of breast cancer Breast cancer is a complicated, heterogeneous disease, mostly accompanied by symptoms such as a mass in the breast, changes in breast shape, size and color, pain in breast or nipple, fluid discharge from the nipple, inverted nipple, dimpling or irritation of the skin. …

Irilone as a progesterone receptor (PR) effect supporter in endometrial and ovarian cancer cell lines   Estrogen and Progesterone receptors (ER, PR) are ligand-induced transcription factor members of the steroid hormone receptor (SR) subfamily of nuclear receptors. Those receptors and their corresponding steroid hormones (estradiol and progesterone) play their roles …

Zotepine as an atypical antipsychotic antagonist Schizophrenia is a chronic, critical condition characterized by collective psychotic signs and symptoms, exhibited as alterations in patient’s thoughts, perception and behavioral attributes. Schizophrenia is mostly accompanied by symptoms that are generally categorized into two major groups: 1: Positive symptoms including hallucinations (auditory, visual, …

Esketamine for Major Depressive Disorder (MDD) treatment Major depressive disorder or MDD is a serious neurological condition that afflicts almost 300 million people around the world. Over the years, various classes of antidepressants have been developed. Although the efforts to manage MDD have been fruitful in many cases, still about …

Novel drugs for autism treatment Autism spectrum disorders (ASDs) are complex and prevalent neurodevelopmental disorders predominantly diagnosed through observation of a wide variety of atypical behavior, expressed by impairments in socialization, communication, thinking, interests, activities and cognitive skills as well as restricted and repetitive behavior. Autism is considered a heterogeneous …

 Metoclopramide as a small molecule of dopamine D2 receptor Dopamine D2 receptor (D2R) has been constructed from various natural amino acids in humans that is encoded by DRD2 gene. This protein (D2R) is the most important receptor for many antipsychotic medicines. The D2R structure has been known using a radiolabeled …

Treatment of Sickle cell disease SCD Sickle cell disease (SCD) is a genetic disorder in which a mutation of the hemoglobin subunit beta (HBB) results in generation of anomalous hemoglobin in shape of a sickle. Hemoglobin (Hb) is a protein existent in red blood cells and is composed of four …

۱۱C-LY2795050 Radiopharmaceutical A receptor into the cells has two main operations when it makes complex with an agonist compound and or an antagonist molecule. The agonist-receptor complex formation causes the receptor activation, but the binding of antagonist molecule to the receptor causes its blocking. In pharmacology, the antagonist compounds have …

Curriculum vitae *************************************** Mehdi Nabati Ph.D. of Organic Chemistry Date of Birth: 22/04/1988 Place of Birth: Maragheh, East Azarbaijan, Iran Marital Status: Single Mobile Number: +989011828140 E-mail: mnabati@ymail.com *************************************** EDUCATION AND RESEARCH Azarbaijan Shahid Madani University, Tabriz, Iran . Ph.D., Organic Chemistry, with Dr. Mehrdad Mahkam, Sept. 2012 – ۲۰۱۵ …