Scientific Reports

Substitution of carbonyl group of ellagic acid with silanediol group for better inhibition of VEGFR-2 Kinase enzyme What is cancer? The major cause of death worldwide is cancer. Surgery, chemotherapeutic agents and radiation which are cancer therapy have not been much efficient in the reduction of cancer occurrence and raising …

Withaferin A (WIT) interaction with β–Tubulin Withaferin A (WIT) Withaferin A (WIT) is an important natural compound extracted from the Indian medicinal plant Withania somnifera. This plant has been used for over 3000 years in Unani Indian medical system. Also, its extracted medicinal compound has been in ayurvedic medicine and …

Design of novel tazarotene derivatives as potential antipsoriatic drugs   What is Psoriasis? Psoriasis is a prevalent chronic inflammatory skin condition afflicting about 2-4% of patients all over the world. Psoriasis is mostly characterized by the skin covered with red, well-defined, hardened plaques with silver and micaceous scale. Complications associated …

The molecular structure and the stability parameters of 99mTc-MDP Medronate, commonly known as methylene diphosphonate or MDP, is the smallest bisphosphonates, recognized as a family of drugs used in treatment of various bone diseases. Bisphosphonates are the structural analogs of native pyrophosphate with a P-C-P backbone instead of P-O-P. The …

FPTT for PET scan of breast cancer Breast cancer is a complicated, heterogeneous disease, mostly accompanied by symptoms such as a mass in the breast, changes in breast shape, size and color, pain in breast or nipple, fluid discharge from the nipple, inverted nipple, dimpling or irritation of the skin. …

Irilone as a progesterone receptor (PR) effect supporter in endometrial and ovarian cancer cell lines   Estrogen and Progesterone receptors (ER, PR) are ligand-induced transcription factor members of the steroid hormone receptor (SR) subfamily of nuclear receptors. Those receptors and their corresponding steroid hormones (estradiol and progesterone) play their roles …

Zotepine as an atypical antipsychotic antagonist Schizophrenia is a chronic, critical condition characterized by collective psychotic signs and symptoms, exhibited as alterations in patient’s thoughts, perception and behavioral attributes. Schizophrenia is mostly accompanied by symptoms that are generally categorized into two major groups: 1: Positive symptoms including hallucinations (auditory, visual, …

Arketamine for Major Depressive Disorder (MDD) treatment Major depressive disorder (MDD) is one of the most infamous and oldest medical conditions determined by disturbances of cognition as well as neurovegetative and psychomotor functions. The World Health Organization estimates the number of individuals afflicted by MDD to be well over 300 …

Esketamine for Major Depressive Disorder (MDD) treatment Major depressive disorder or MDD is a serious neurological condition that afflicts almost 300 million people around the world. Over the years, various classes of antidepressants have been developed. Although the efforts to manage MDD have been fruitful in many cases, still about …

Novel drugs for autism treatment Autism spectrum disorders (ASDs) are complex and prevalent neurodevelopmental disorders predominantly diagnosed through observation of a wide variety of atypical behavior, expressed by impairments in socialization, communication, thinking, interests, activities and cognitive skills as well as restricted and repetitive behavior. Autism is considered a heterogeneous …