Scientific Reports

 Metoclopramide as a small molecule of dopamine D2 receptor Dopamine D2 receptor (D2R) has been constructed from various natural amino acids in humans that is encoded by DRD2 gene. This protein (D2R) is the most important receptor for many antipsychotic medicines. The D2R structure has been known using a radiolabeled …

Treatment of Sickle cell disease SCD Sickle cell disease (SCD) is a genetic disorder in which a mutation of the hemoglobin subunit beta (HBB) results in generation of anomalous hemoglobin in shape of a sickle. Hemoglobin (Hb) is a protein existent in red blood cells and is composed of four …

Introducing a novel source of carbene on pyridine ring for the first time ۲,۶-Diaminopyridine (2,6-DAP) is formally prepared from pyridine by substitution of the 2 and 6 positions with an amino group under severe conditions. It is a medium-production-volume chemical used as a pharmaceutical intermediate and a hair dye coupler …

۱۱C-LY2795050 Radiopharmaceutical A receptor into the cells has two main operations when it makes complex with an agonist compound and or an antagonist molecule. The agonist-receptor complex formation causes the receptor activation, but the binding of antagonist molecule to the receptor causes its blocking. In pharmacology, the antagonist compounds have …